Abstract
An experimental study with the objective to evaluate the acute toxicity study and anti-ulcerative property of the polyherbal formulation named-ASC01 (formulated in the same institute) was performed as per OECD guidelines 423. The polyherbal ayurvedic formulation (PHAF) is a scientifically developed combination of herbs that contains herbal ingredients like Yashtimadhu, Shatavari which have reported antiulcer activity. Firstly an acute toxicity study was formulated (as per OECD guidelines 423) the animals were observed for signs of convulsions, tremors, circling, depression, excitement and mortality. No abnormal sign of symptoms were observed in any of the animal fed with the PHAF at the dose upto 5000 mg/kg body weight. No mortality was observed in any of the animals indicating its safety. The anti-ulcer property of the polyherbal formulation was evaluated on wistar albino rats grouped into 4 groups (n=6). The findings showed that the said polyherbal test extract (ASC01) helped in reversing duodenal and peptic ulcer in murine models.
