Abstract
The objective of the study was to design and develop Gastroretentive dosage form for Losartan potassium using floating bioadhesive tablet approach with Polyox Wsr 1105 & HPMC K 4M polymers & sodium bicarbonate & citric acid as gas generating agents to reduce floating lag time. Optimization study was carried out by using 32 factorial design to prepare formulations. Vit E is added as a antioxidant for development of this gastroretentive dosage form of Losartan potassium by using Polyox to avoid stability risk associated with Polyox .The concentration of polymers was considered as independent variables whereas Swelling index, bioadhesive strength, % drug release at 10 hrs, of the tablets were utilized as dependent variables .Tablets were prepared by direct compression method. The prepared tablets were thoroughly evaluated for physical properties, floating, swelling, bioadhesive and in vitro release behaviors .The optimized F4 gastroretentive batch, gave floating lag time of 21±2 sec and with in vitro dissolution of 98.71 % in 12 hrs with appropriate bioadhesive property. After stability studies, no significant change was observed in floating lag time, bioadhesive strength, total floating duration and drug release rates. These results suggest that this floating bioadhesive gastroretentive dosage form is a promising approach for the oral delivery of Losarten potassium by improving its Gastric residence time for better management of hypertension.
