Abstract
This study was done to optimize and evaluate Tramadol hydrochloride loaded Solid Lipid Nanoparticles by using particle size and zeta potential analysis, Differential scanning calorimetry and Scanning electron microscopy. Tramadol hydrochloride was obtained as a gift sample from Indeus Life Sciences. Precirol ATO 5 and Compritol 888 ATO was obtained from Gattefosse Ltd. Stearic acid, Glyceryl mono stearate self emulsifying, chloroform, ethanol, isopropyl alcohol, Tween80, Poloxamer 188 were also used for the formulation of solid lipid nanoparticles (SLN). Attempts were made to optimize SLN by Solvent evaporation method. The solid lipid nanoparticles were successfully formulated which were in the size range of 300-400nm with zeta potential between -20 to -30mV. The SLN exhibited circular structure with better encapsulation efficiency. Compatibility between the drug and excipients was confirmed by Differential scanning calorimetry. Solid lipid nanoparticles of Tramadol hydrochloride with sufficient drug content can be a promising approach in context to formulation of topical gels and creams.
