Abstract
A rapid, precise, accurate, sensitive and selective first-order derivative spectrophotometric method was developed for the simultaneous determination of escitalopram oxalate and Flupentixol dihydrochloride in pharmaceutical dosage form. The first-order derivative spectra were obtained and determination was made at 226 nm (ZCP of Flupentixol dihydrochloride) for escitalopram oxalate and at 237 nm (ZCP of escitalopram oxalate) for Flupentixol dihydrochloride. In this method, linearity was observed in the ranges of 20-120 g/mL for escitalopram oxalate and 1-6 g/mL for Flupentixol dihydrochloride. The % recovery was within the range between 98 and 102%, and % relative standard deviation for precision and accuracy of the method was found to be less than 2%.The method is validated as per international conference on harmonization guidelines. The method can be successfully applied for the simultaneous analysis of both drugs in pharmaceutical dosage forms. These methods are simple, accurate and rapid, those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.
