Abstract
Arthritis is the painful disease caused in the joints of the bone. Rheumatic arthritis and osteoarthritis are the various disorders causes inflammation and pain. Various route of administration like oral, parenteral, topical and nasal routes are used but it may causes damage in gastro-intestinal tract, irritation hence it is administered through intra-articular route. It reduces the side effects and infections because it is given directly to the joints. Drugs are injected directly to the site which shows better action than oral delivery. When it is administered through other routes chances of degradation of drugs may takes place; which decreases the bioavailability of the drug or concentration of the drug. Drugs used for treatment of arthritis include steroids, non-steroidal anti-inflammatory drugs, anti-rheumatic drugs etc. Drugs like corticosteroids, glucocorticoids, ibuprofen, ketoprofen, selective cyclooxygenase 2 inhibitors are also used for treatment of arthritis which shows quick onset of action on the pain. They show the action as analgesic and antipyretics by reducing the pain in the bone joints and bones. NSAIDs are mainly used in acute and chronic conditions. Apart from the conventional formulations, diverse approaches like hydrogels, hyaluronic acid, microparticles, nanoparticles etc. have been proposed and used in order to improve the sustain release of the drug after administration; thereby improving the efficacy. Present article encloses a comprehensive review of various novel drug delivery systems implied for augmented arthritis therapy.
