Abstract
In present study, an attempt has been made to analyse the impact of sub lethal concentrations of heavy metal arsenic on the metabolic fuel molecules in the liver tissues of Labeo rohita and the preventive role of methylcobalamin (vitamin B12) against the changes of arsenic. Liver is a target organ of arsenic toxicity. Fish liver plays an important role in uptake, accumulation, bio-transformation and excretion of arsenic. We observed decrease in protein, lipid and glycogen content in arsenic treated fishes after 30 days and the value decreases more significantly in later part of experiment while as less decrease was found in fishes which were treated with arsenic in accommodation with methylcobalamin, when compared with control group. From the above observation we come to the conclusion that methylcobalamin ameliorates the toxicity of arsenic may be through methylation process.
