Abstract
Several techniques are used to increase the aqueous solubility of poorly water soluble drugs. Hydrotropic solubilisation technique is one of them. In the present investigation hydrotropic solution of urea (5M) has been employed as solubilizing agent to solubilization poorly water soluble drug Simvastatin by spectrophotometric determination in ultraviolet region. Simvastatin shows maximum absorbance at 250 nm. Beer’s law was obeyed in the concentration range of 50-200 μg/ml. Results of analysis were validated statistically and by recovery studies. From this we concluded that proposed method is new, simple, environment friendly, accurate and cost effective and can be successfully employed in routine analysis of Simvastatin in tablets. Hydrotropic agent urea did not interfere in spectrophotometric estimation.
