Abstract
Objective: To evaluate herb drug interaction between ethanolic extract of Aloe vera with glipizide in streptozotacin induced diabetic rats. Methods: The streptozotacin induced diabetic rats were treated with ethanolic extract of Aloe vera at selective doses (20, 40 and 80 mg/200g, p.o), glipizide (0.18mg/200g, p.o) and combination of high dose (80 mg/200g, p.o) of ethanolic extract of Aloe vera and glipizide. The Blood glucose level was estimated at 0, 7, 14, 21 and 28 days. Body weight of the rats of all the groups was recorded before and after the study period of 28 days. Results: Significant hypoglycemic effect observed in ethanolic extract of Aloe vera and glipizide treated groups. The decreased blood glucose levels were observed higher in combination of drug treatment group than single administration groups, and body weight also improved significantly in streptozotocin induced diabetic rats. Conclusion: The results clearly revealed ethanolic extract of Aloe vera augments the hypoglycemic effect of glipizide in streptozotacin induced diabetic rats. Further studies are recommended for clinical benefits in humans to reduce the glipizide dose and avoid the adverse effect of glipizide.
