Abstract
Clinacanthus siamensis is a medium sized perennial shrub grows up to 2m in height belonging to the family Acanthaceae. It is distributed throughout the Western Ghats growing as an under shrub. The Leaves, roots and stem are used traditionally as Poison bites, inflammation, traumatic edema and swelling due to poison stings. The present study aimed at the evaluation of the anti-inflammatory, anti-arthritic and cox1 and cox2 inhibitory activity of the methanolic extract of Clinacanthus siamensis. Invitro method was estimated by human red blood cell membrane stabilization (HRBC) method and cox1 and cox2 inhibitory activity and invivo method was estimated on the formalin induced arthritic inflammation. Both the methods showed significant anti-inflammatory property of the methanolic extract. The MECS at a concentration of 400μg/ml showed potent activity on comparing with the standard drug.
