Abstract

Chalcones are 1,3-diphenyl-2-propene-1-one, in which two aromatic rings are linked by a three carbon α, β-unsaturated carbonyl system. These are abundant in edible plants and are considered to be precursors of flavonoids and isoflavonoids.In the development, chalcones do not only comprise derivatives of trans-1,3-diaryl-2-propen-1-ones, but also their analogs. Chalcones isolated from nature show exotic structure, which is sometime unrecognizable directly. The aim of this review to give summary of methods for synthesis of Chalcones, its chemical modifications to flavonoids, flavanone,oxazoles.Furthermore the bi-electrophile character of chalcone makes them more attractive to be used as synthon in the synthesis of heterocyclic compounds, such as pyrazoline, pyrimidinone, and benzazepine, through cyclo-condensation reaction with a bi-nucleophilic species. This article highlights the structure diversity of chalcone whether from nature or synthetic origin and various synthetic methods of chalcone are discussed.