Abstract
Aceclofenac is the potent phenyl acetic acid derivatives having effective anti-inflammatory and analgesic properties. Paracetamol is the major metabolite of Phenacetin and has similar analgesic-antipyretic action but it does not possess anti-inflammatory or anti rheumatic activity. Aceclofenac and Paracetamol are practically insoluble and for poorly soluble orally administered drug, the rate of absorption is often controlled by the rate of dissolution. Faster disintegration of tablets delivers a fine suspension of drug particles resulting in higher surface area and faster dissolution. Formulation of fast dispersible tablet of aceclofenac and paracetamol using wet granulation technique and their evaluation has been attempted in the present study. The behavior of superdisintegrants likes Croscarmellose sodium, Crospovidone and sodium starch glycolate in the formulation has also been studied. Said tablets were evaluated for different parameter like Disintegration, Drug Content Uniformity and In- vitro drug release studies etc. Results show that Croscarmellose sodium is having good disintegrant property with increasing concentration. But in combination with Crospovidone and sodium starch glycolate it showed better disintegrant property. Results also revealed that if the concentration of sodium starch glycolate increases, disintegration time increases. From the behavior of superdisintegrants, it can be concluded that superdisintegrants can work better in combination with each other than single. Hence, it was worthwhile to formulate and evaluate dispersible tablets of aceclofenac and paracetamol using this disintegrants.
