Abstract
Nanogels are nanosized hydrogel particles formed by physical or chemical cross-linked polymer networks. The porous nanogels have been finding application as anti-cancer drug and imaging agent reservoirs. The advantageous properties of nanogels related to the ability of retaining considerable amount of water, the biocompatibility of the polymers used, the ability to encapsulate and protect a large quantity of payload drugs within the nanogel matrix, the high stability in aqueous media, their stimuli responsively behavior potential, and the versatility in release drugs in a controlled manner make them very attractive for use in the area of drug delivery. Nanoparticle-based medication can enhance the viability and security of certain anticancer medications. Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. A targeted nanogel can encapsulate a wide range of drug chemotypes, including biological, small molecule, and cytotoxic agents; display targeting ligands and polymeric coatings on the surface; enhance drug retention within the nanogel core after photo-cross-linking; and retain therapeutic activity after lyophilization allowing for prolong storage. This study shows that the curcumin is a multi-functional and pharmacologically safe natural agent having anti-inflammatory, anti-oxidative and anti-tumor properties.
