Abstract

Pulsatile drug delivery system is the new approach to overcome patient non-compliance over commercially used dosage forms. These techniques also help in treating the disorders based on circadian paradigm. In this article, an attempt has been made to discuss the Chronotherapeutics approach to increase the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and best tolerated. Biological plays a pivot role in the tolerance to any medicine given for the treatment of any disorder. This system enables the active drug for target action and inflated bioavailability with increased pharmacokinetic as well as pharmacodynamics profile of active moiety and also stated all the techniques involved in pulsatile system with their brand name. Various disease are discussed which is affected by circadian rhythm such as Cardiovascular disease, Diabetic, Alzhemier Disease, Parkinson’s Disease, Bronchial Asthma and Rheumatoid Arthritis. The author attract an attention to establish an importance of marketed pulsatile drug delivery technique in medical simultaneously in pharmaceutical Research & Development and the various disease associated with the pulsatile system of the body.