Abstract

In the present work, an attempt has been made to develop gatroretentive floating controlled release tablets of glimepiride by selecting HPMC K4M and xanthan gum as retarding polymers. The polymers are used in different ratios, all the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters such as hardness, thickness, friability, percent drug content, weight variation tests and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F2 formulation showed maximum percent drug release i.e., 100% in 12 hours. Hence it is considered as optimized formulation with the least possible concentration of polymers. 32 full factorial design was applied for the optimization of formulations. It was observed that the combination ratio of HPMC K4M, xanthan gum at 20:12 has distinct effect on in vitro drug release profiles when compared to all the other combinations of polymers.