Abstract
Various substituted benzaldehydes were converted to corresponding oximes and subsequently esterified with undecenoic acid to obtain novel undecenoic acid based aldoxime esters. The structures of the prepared oxime esters were confirmed using NMR, IR and mass spectral data. These oxime esters were evaluated for their in vitro antimicrobial and antioxidant activities. It was observed that the oxime ester derived from 3-hydroxy benzaldoxime (compound 3j) exhibited promising antimicrobial activity against three gram positive organisms and also against a fungal strain. In addition, the derivative showed good activity in biofilm inhibition assay. In the antioxidant evaluation, oxime ester 3k derived from 2, 3- dihydroxy benzaldoxime exhibited excellent antioxidant activity as observed by DPPH radical scavenging activity, superoxide free radical scavenging activity and inhibition of lipid peroxidation assay as compared to commercial antioxidants. From the present study, compound 3j was found to be the most potent antimicrobial agent and compound 3k was found to be promising antioxidant.
