Abstract
As a development of recent drug discovery techniques, there has been an increase in the number of novel pharmacologically active compounds that are lipophilic in nature. It is indeed challenging for pharmaceutical researcher to enhance the oral bioavailability of such molecules. One of the most well-known and commercially suitable formulation approach for resolving these problems is self-emulsifying drug delivery systems (SEDDS). SEDDS has given promising results in improving the oral bioavailability of poorly water-soluble and lipophilic drugs. Highly lipophilic drugs can be dissolved in these systems and administered as solid dosage form for oral administration. This system gets released in the gastrointestinal tract, where it disperses to form a fine emulsion with the help of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways. So, these are the additional advantage associated with this system. For lipophilic drug compounds that exhibit dissolution-rate-limited absorption, SEDDS can offer an improvement in rate and extent of absorption, resulting in reproducible drug concentration in blood. Possibility of the system to adsorb on the solid carrier has gained popularity because systems can be administered as a unit dosage form for oral administration. It was concluded that although a lot of work has been done, still there is scope for exploring this technique for enhancement of poorly soluble drug.
