Abstract
Diabetes mellitus leads to the metabolic abnormalities and is characterized by hyperglycemia resulting from dysfunctional insulin secretion. Although, oral hypoglycemic agents or insulin are the mainstay of treatment diabetes, they have prominent side effect, and fail to significantly rework the course of diabetic complications. Use of herbal drugs and neutraceuticals are safer and more efficacious than synthetic drugs. Use of neutraceuticals and herbal drugs become main stream globally. The Momordica charantia, commonly known as bitter melon, is used as herbal remedy for diabetes from long back in ayurvedic literature. The various components of this putative herb have been reported to express hypoglycemic activity. An attempt was made to cognize the mode of action for alkaloid using bioinformatics tools of molecular dynamic and drug designing. The common alkaloids of Momordica charantia, namely, charantin and stigmasteryl glucoside were used as ligands and there binding affinity with insulin was studied by in silico docking tools. Thus, the crude alkaloid extracted from bitter melon may be an alternative therapy potential use for lowering glucose level in diabetic patents. Derivative compound of the alkaloid can be further studied for better remedy as ligand compound quantitative structure activity relationship. So for, compound known as oleanolic acid glycoside has been observed to improve glucose tolerance in type II diabetes.
