Abstract
Simple and cost effective spectrophotometric method was described for the determination of Olmesartan Medoxomil in pure form and in pharmaceutical formulations. The method is based on the formation of colored chromogenic when the drug reacts with Chloramine – T and Gallocyanine in acidic medium. This method was applied for the determination of drug contents in pharmaceutical formulations and enabled the determination of the selected drug in microgram quantities (0.5 to 3.0 mL). No interferences were observed from excipients and the validity of the method was tested against reference method. The colored species has an absorption maximum at 540 nm for Olmesartan Medoxomil and obeys beer’s law in the concentration range 4-24 mg/mL of Olmesartan Medoxomil. The apparent molar absorptivity was 1.74*104and sandell’s sensitivity was0.0226. The slope is1.2423 the intercept of the equation of the regression line is 0.2699. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Olmesartan Medoxomil in pharmaceutical formulations.
