Abstract
Indapamide is an antihypertensive and diuretic. It is used in the treatment of hypertension. Three simple, sensitive, accurate and precise spectroscopic methods have been developed for the estimation of Indapamide in bulk and in pharmaceutical formulation. The drug obeyed Beer’s law in the concentration range of 5-25µg/ml in methanol. The regression equation and the correlation coefficient were found to be y = -0.00044x+0.00068, R2 =0.994 for second order, y = -0.00009x-0.00028, R2 = 0.997 for third order and y = -0.00001x-0.00005, R2 = 0.998 for fourth order derivative spectroscopy. The detection wavelengths were shown at 254 nm, 221 nm and 256 nm respectively for second, third and fourth order spectra. The proposed methods were validated for accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) as per ICH guidelines. The authors aim to propose a fast and accurate method compared to other derivative methods suitable for routine quality control analysis of Indapamide tablet formulations.
