Abstract
Cancer is lifethreatning disease despite of large number of therapies is developed now a day. But any single therapy doesn’t ensure higher cure rate. Each therapy having some limitation and hurdles which can affect other normal tissue and organs. The biology of cancer is a complex at molecular and genetic levels which creates problems in its treatment for cancer. due to alteration in different molecular like proteins , enzymes , growth factors ,cell cycle proteins ,cell components, leads to change in cellular normal pathway. In normal conditions, all DNA within the cell is replicated uniformly and only once per cell cycle but due to genetic instability by different carcinogens and also congenital genetic mutation occurred in gene Genetic level mutation which difficult to treat by different therapies. Different treatment approaches are developed now days to target various components of cancer cell like targeted therapies, hormonal therapies, biological therapies, and other novel targeted therapies, in which each therapy having some limitations and toxicity for all types of cancer. To avoid limitation of current strategies for treatment of cancer there is need to develop new novel tools and achieve maximum selectivity for current therapies at cellular level. New research methods and tools like gene Hunting and DNA sequencing, DNA arrays genomics and proteomics, Screening methodologies, new chemo preventive agents, which helps in future for development of successful cancer treatment. This paper describes a brief outlines on problems occurred in cancer therapy and treatments.
