Abstract
The objective of this research is to develop a new oral drug delivery system utilizing both the concept of controlled release and mucoadhesion to obtain a unique drug delivery system which would remain in stomach for longer period. Captopril is a potent ACE inhibitor. Given orally, Captopril has a bioavailability of 65-70%. The drug is cleared with a half life of about 2 h. The research involves the formulation, optimization and evaluation of gastroretentive mucoadhesive microspheres. The mucoadhesive microspheres were successfully developed by Ionotropic gelation technique, using Sodium alginate, and Sodium CMC as mucoadhesive polymers in various proportions. Further, the prepared mucoadhesive microspheres were characterized for particle size, morphology, entrapment efficiency, mucoadhesion, in vitro drug release, release kinetics, compatibility studies(DSC) and stability studies. This research involves the formulation, optimization and evaluation of gastroretentive mucoadhesive microspheres via 22 factorial design approach using mucoadhesive polymers, i.e., Sodium CMC and Sodium Alginate on the basis of mucoadhesive strength & In-vitro drug release. Out of different formulations prepared, ‘F2’ formulation with Sodium Alginate & Sodium CMC (6:1) was found to be best optimized formulation showing the highest modified release (85% in 9 h) along with good mucoadhesion property.
