Abstract
In the present work, chewable tablet of ibuprofen were prepared using novel coprocessed excipient consisting of dicalcium phosphate and magnesium stearate, in different ratios. The developed excipient were evaluated for angle of repose, cars index and hausners ratio in comparison with physical mixture of excipient. The angle of repose of developed excipient was found to be less than 200, cars index in the range of 10-20% and hausners ratio in the range of 1.10 -1.17. Chewable tablet of ibuprofen were prepared using the coprocessed excipient and evaluated for pre compression and post compression parameters. In vitro drug release pattern were taken in PBS- 6.8 and short term stability study (at 400C/75% RH for 3 months),drug excipient interactions (IR,DSC) were studied. Among the designed formulations, the formulation (B1) containing (21:0.5 mixture of dicalcium phosphate and magnesium stearate) emerged as the overall best formulation, based on drug release characteristics in PBS-6.8 compared to other formulation. Short term stability studies on promising formulation indicating that there were no significant changes in drug content and in vitro drug release. Thus successful development of a novel coprocessed excipient and formulation of chewable tablet of ibuprofen fulfils the objective of work.
