Abstract

Vitamin D is of particular interest to dermatologists for two vital reasons: it is synthesized in the skin upon exposure to UV light, and it is an significant treatment option for psoriasis and other skin diseases. Studies have shown that vitamin D has dose-dependent special effects in the skin, including the modulation of growth factor and cytokine synthesis and signaling. It also reduces the synthesis of IL-1α and IL-6, resulting in decreased inflammation. It also increases the synthesis of platelet-derived growth factor (PDGF) in keratocytes cells to encourage wound healing and TNF-α to promote keratinocyte differentiation. in addition, vitamin D analogs have comedolytic activity. Certain these effects, vitamin D may be used in the treatment of some skin disorders. On the other hand, the exhibition of a role for vitamin D in various diseases, including osteoporosis, cancer, autoimmune diseases and dermatological diseases, suggests clinical applications for vitamin D and its analogs. As mentioned beyond, numerous studies have shown that vitamin D has dose-dependent antiproliferative effects. In addition, vitamin D can reduce the risk of skin infection. Auxiliary, vitamin D deficiency is related to dermatological diseases such as psoriasis, vitiligo, atopic dermatitis (AD), acne, rosacea, and skin cancer. For that reason, the main aim of this study was to review the role of vitamin D in dermatological conditions.