Abstract

In the present study bilayer tablet of famotidine with antacids (aluminium hydroxide and magnesium hydroxide) layer are prepared. The inner sustained release layer of famotidine consist controlee release polymer HPMC K4 M and HPMK100M at different concentration .and the combination of citric acid ,tartaric acid and sodium bi carbonate used as a effervescent for outer immediate release layer of antacid .The inner layer of famotidine shows the sustained release effect up to 9 hrs. And the immediate release layer of antacids shows rapid dispersion time between 8-12 seconds. The prepared tablets were evaluated for their post compression parameters, physical characteristics and in-vitro release study. The drug content of famotidine was found between the ranges of 98.25-99.30. The Cumulative percent drug release of optimized formulation (FB5) after 10 hours were found to be 98.03 %. Fitting the in-vitro drug release data in to krosmeyer-peppas model the n value found to be approx 1 that shows that all the six formulations followed the mechanism of diffusion. FB5 formulations were selected for stability studies stored at 300C±20C, 65 ± 5% RH and subjected to stability studies up to 90 days. Drug content and cumulative percent drug release after stored formulation for 45 days of optimized formulation FB5 were found to be 98.90. The % similarity of cumulative percent drug release before and after was found to be 87%. It showed that the formulations are physically and chemically stable.