Abstract
The objective of the current work is to develop solid self-nanoemulsifying drug delivery systems (S-SNEDDS) of a poorly water soluble drug, lopinavir in order to enhance its in vitro dissolution rate. This method is developed to improve the solubility of the BCS this class II drug. The solubility of lopinavir is determined in different oils, surfactants and co surfactants. Lopinavir SNEDDS were prepared using Capryol 90 (oil, 20% w/w), Chremophore EL (surfactant, 7.1% w/w) and Transcutol P (co-surfactant, 28.4% w/w). The standard graph was constructed by dissolving the drug in methanol and validated by UV Spectroscopy. The prepared formulations were evaluated for self emulsifying ability and phase diagrams were constructed to optimize the system. These systems were further characterized and suitable formulation was selected. The selected formulation is selected for conversion into solid by using adsorbent neusillin US2 (22.2 % w/w). The particle size distribution, Zeta potential and poly dispersability index (PDI) of the solid formulation were found to be 158.5 nm, -26.9 mV and 0.194 respectively of the selected formulation. Dissolution studies were also carried out. % drug release of pure drug and solid SNEDDS were found to be 24.58% and 93.61% respectively. The solubility of lopinavir formulated as S-SNEDDS increased approximately four times compared to that of the pure drug.
