Abstract

The main aim of the study is to formulate solid self emulsyfying drug delivery systems of poorly water soluble drug Ritonavir to enhance the dissolution rate .Solubility of Ritonavir was checked in various oils, surfactants, co- surfactants and different formulations were prepared using selected ingredients. These systems were evaluated for self emulsyfying property and phase diagrams were constructed, which were then further charecterised to optimize the formulation. The formulation containing pippemint oil (25.7% w/w), Transcutol (53.23% w/w), Chremophore (15.845% w/w) was found to be stable and was selected for conversion into solid snedds by using neusilin as a carrier. Prepared solid snedds were further charecterised and the particle size distribution, zeta potential and poly dispersibilityindex(PDI) were found to be 30.21nm,-14.35 and 0.354 respectively. Dissolution studies were also carried out which showed an enhancement in dissolution rate of s-snedds of Ritonavir (72.86%) compared to the pure drug (66.65%).