Abstract
A selective, precise, isocratic and accurate stability indicating reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of Troxerutin and Calcium Dobesilate the tablet dosage form. As per the literature review no major articles were seen which had the work of the drugs in the combined dosage form. A chromatographic separation was achieved on reverse phase BDS Hypersil C18 column (250 ×4.6 mm, 5μ). The mobile phase consists of mixture of 0.1% Triethylamine buffer and methanol (55:45). The pH adjusted to 4.5 using Orthophosphoric acid. The flow rate was 1 ml/min and the effluents were monitored at the detection wavelength of 225 nm.
