ABSTRACT
An attempt has been made to prepare the various trails of extended release film coated matrix tablets of Felodipine using polyoxyl 40 hydrogenated castor oil (Cremophor RH40) as solubilizer with the different grades of hydroxy propylmethylcellulose (HPMC) as the release retardant polymers by wet granulation method. The prepared granules and tablets were evaluated for the various pre and post compression parameters. The dissolution profile of the various trails with the dissolution profile of marketed formulation was compared by using Food and Drug Administration-recommended similarity factor (f2) determination. The formulation trail containing methocel E50 premium, with a similarity factor (f2) of more than 80 % was selected as the optimized formulae for scale-up batches. Finally, it was compared with the in-vitro release profile of the marketed product with various dissolution media such pH 6.5 phosphate buffer with 1% sodium lauryl sulfate and 1% (w/v) polysorbate 80 in water. The results were found to be satisfactory.
