ABSTRACT
A simple, efficient, accurate, precise and new spectrophotometric method has been developed for spectroscopic estimation of Lamotrigine in bulk and in tablet dosage forms. In the present study, a very slightly soluble drug, Lamotrigine has been solubilised in water using hydrotropic blend containing 5% urea, 5% sodium benzoate, 10% nicotinamide, and scanned between 200-400nm taking respective reagent blanks in a double beam spectrophotometer. The λmax was found to be 306nm and Lamotrigine was found linear in the range of 10-50 mcg/ml. The mean percent Lamotrigine estimated in Lamotrigine tablets were 100.07 (formulation I) and 99.05 (formulation II). These values are very close to 100, indicating accuracy of proposed method. The proposed method was validated statistically by low values of statistical parameters such as standard deviation, per cent coefficient of variation and standard error. In this proposed method, organic solvents are not used which makes it eco-friendly.This mixed hydrotopy, a novel approach can be used not only for estimation but also used to increase solubility and release of poorly water soluble drugs.The hydrotropes used are cost efficient, safe and non-harmful to environment, hence it can be employed for routine analysis of Lamotrigine in bulk and in tablet dosage forms.
