Abstract
A fast, robust RP-HPLC method was developed for simultaneous determination of Bisoprolol fumarate and Amlodipine besylate in tablets. The mobile phase was mixture of Methanol: Acetonitrile: 50mM Potassium dihydrogen phosphate buffer KH2PO4 (25:30:45 v/v) at pH 3.0 at 1 ml/min. The stationary phase was C18Intersil 4.6 x 150 mm (id). UV detection was performed at 267 nm.
