Abstract

The present research work discusses the formulation and evaluation of controlled release floating matrix tablets of metoprolol by using natural polymers by direct compression method. Floating drug delivery system mainly aims at increase in drug gastric retention time. Metoprolol succinate is ß2 selective blocking agent which is used in management of hypertension. Metoprolol succinate floating drug delivery system was prepared using natural polymers like xanthan gum, Karaya gum and gas forming agent Sodium bicarbonate. Tablets were prepared using directly compression and were evaluated for buoyancy test, swelling study, drug content and In Vitro release profile. The prepared tablets showed acceptable physicochemical characteristics. All the prepared batches showed fine In Vitro buoyancy. The release data were subjected to different models zero order, first order Higuchi and Pappas in order to evaluate their release kinetics and mechanisms. Floating matrix tablets of Metoprolol succinate can be prepared well with combination of Xanthan gum and Karaya gum that shows controlled drug release up to 12 hours.