Abstract
The present study is aimed at evaluating the adaptogenic activity of the methanolic extract of Tamarindus indica (METI) leaves using various acute stress experimental animals models. The various biochemical parameters were estimated to assess the study, like Glucose, Cholesterol, Triglycerides, Total protein, SGPT, SGOT, BUN, RBC, WBC (Neutrophils, Lymphocytes, Monocytes, and Eosinophils). In Swimming endurance model animals were divide in to 3 groups (six rats/group), after 7 days dosing of METI (500mg/kg, P.O.) the treated group was compared with normal group showed a significant (p<0.01) increase in swimming time, significantly reduction on biochemical and haematological parameters. In Restrain model animals were divided into 4 groups (six rats/group), test group was treated for 14 days with METI (500mg/kg, P.O.) and compared with negative control group showed significantly reduction on biochemical, haematological parameters and the weight of the spleen, adrenal gland were significantly increased and weight of the liver was significantly decreased. In Cold stress model animals were divided into 4 groups (six rats/group), test group was treated for 10 days with METI (500mg/kg, P.O.) and compared with negative control group showed significantly reduction on biochemical parameters, haematological parameters, where the weight of the spleen, adrenal gland were significantly increased and the weight of the liver was significantly decreased. In writhing test model animals were divide into 3 groups (six mice/group), after 7 days dosing of METI (500mg/kg, P.O.), the treated group was compared with normal group which showed a significant (P<0.05) reduction in the number of writhing. These results suggest that Tamarindus Indica have positive adaptogenic activity.
