Abstract
The novel 5 – substituted – N - (5 – aryl - 1, 3, 4 – oxadiazol – 2 - yl) benzoxazol – 2 - amines were synthesized evaluated for their antimicrobial and in - vitro anti-inflammatory activities. The 5 – substituted – 2 - aminophenol was treated with Cyanogen bromide to oxadiazole moiety. That was treated with phenylchloroformate to get benzoxazolecarbamate. The benzoxazolecarbamate was treated with hydrazine hydrate to get benzoxazolecarbamide. That was treated with bromine to get the titled compounds. The chemical structures of these compounds were confirmed by IR, PMR and Mass data. The titled compounds were evaluated for their anti-inflammatory activity by rat paw edema method and antimicrobial activity by cup plate method.
