Abstract

Amlodipine besylate is a vasodilator in which reduces blood pressure. Since, the drug has low bioavailability, it can be increased by enhancing solubility in stomach. The Liqui-Solid compacts of amlodipine besylate having improved solubility were prepared and the dissolution profile is noted. The dispersions of amlodipine besylate were prepared in different concentrations and compressed. The resultant compacts are evaluated for their drug content, flow properties, disintegration & dissolution rate. The amlodipine loaded liquid-solid compacts are prepared using various carrier materials: Micro crystalline cellulose PH101, PH102, PH 200, coating materials: Aerosil& non-volatile solvents: Propylene glycol, Tween 80, PEG 400, Liquid paraffin. Fourier transform infra-red spectroscopy (FTIR) was used to evaluate the drug-polymer interaction. The amlodipine compacts shows good wettability, rapid disintegration, and acceptable dissolution rate compared to the conventional tablets. The cumulative percent drug release of formulation LS-F11 & LS-F13 shows 98% of which greater than marketed conventional tablets of amlodipine besylate (83%).