Abstract
Chalcones and its derivatives have attracted increasing attention due to numerous pharmacological applications. They have displayed a broad spectrum of pharmacological activities. DMF/POCl3 complex was used for intramolecular cyclization and cyclodehydration of imidazolinones (7a-e). A new series of six substituted imidazolone-chalcone derivatives (9a-f) have been synthesized by the condensation of imidazolones (7a-e) with various aldehydes (4a-e). The precursor was synthesized by the reaction of arylidene-2-phenyl-oxazolones (5a-e) with p-aminoacetophenone (6). Structures of the intermediate and final compounds were confirmed by IR, MS and NMR studies. In this present work, imidazolones linked chalcones were synthesized in presence of general reagents, at a faster rate in excellent yields. All the final compounds (9a-f) were screened for their anticancer and antioxidant activities by MTT assay on various cell lines and Nitric Oxide scavenging assay respectively. All the compounds have good to excellent activity.
