Abstract
A series of five 4-(4-(dimethylamino)benzylidene)-1-(4-(3-(substituted aryl)acryloyl) phenyl) -2-phenyl-1H-imidazo-5(4H)-ones (9a-e) have been synthesized by condensation of 1-(4- acetylphenyl)-4-(4-(dimethylamino)benzylidene)-2–phenyl-1H-imidazol-5(4H)-one (7) with different aryl aldehydes (8a-e). DMF/POCl3 complex was used for intramolecular cyclization and cyclodehydration of imidazolinones (7). The precursor was synthesized by the reaction of 4-(4-(dimethylamino) benzylidene)-2-phenyloxazol-5(4H)-one (5) with p-aminoacetophenone (6). The structures of the newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, Mass spectral studies and elemental analysis. All the synthesized final compounds were screened for their anticancer and antioxidant activity. Among all the screened compounds 9d showed potent antioxidant activity and 9c showed potent anticancer activity.
