Abstract

Calophyllum inophyllum L. has been used as folk medicine in the treatment of ocular burn and it has demonstrated potential pharmacological activities. The aim of the study is to perform preliminary phytochemical screening, and to evaluate the nootropic and antidepressant activity effect of methanolic extracts of Calophyllum inophyllum. Calophyllum inophyllum leaves and stem bark were extracted using methanol as solvent by Soxhlet apparatus. The percentage yield of CILE was found to be 16.27% and percentage yield of CISBE was found to be 17.62%. Preliminary phytochemical screening revealed the presence of alkaloids, carbohydrates, glycosides, saponins, tannins, flavonoids, proteins, amino acids and steroids. Doses up to 2000mg/kg were found to be safe after acute toxicity tests. The results for tail suspension test and forced swim suggest antidepressant activity and the electro shock induced amnesia and diazepam induced amnesia suggest nootropic activity of the extract with p value<0.005.