Abstract
Thiazole derivatives are present in many natural and synthetic products with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, anti-inflammatory activities. Thiazole derivatives particularly amino thiazoles play a vital role in pharmaceutical practice owing to their wide biological activities. In continuation to these efforts and with an objective to develop novel and potent therapeutic agents of synthetic origin, it was decided to synthesize certain thiazole prepared by reacting protected acetophenones like 1-[4-(2-Amino-thiazol-4-yl)-phenyl]-pyrrole-2,5-dione (2a), synthesized by reacting maleic anhydride with p-amino acetophenone, 2-[4-(2-Amino-thiazol-4-yl)-phenyl]-isoindole-1,3-dione (2b), synthesized by reacting phthalic anhydride with p-amino acetophenone, N-[4-(2-Amino-thiazol-4-yl)-phenyl]-benzamide (2c), synthesized by reacting benzoyl anhydride with p-amino acetophenone. These thiazoles were further reacted with various aldehydes in ethanol to form Schiff bases [2a1-5, 2b1-2, 2c1-5]. The structure of the new synthesized compounds were authentically establishedby their Rf value, melting point, IR, 1HNMR, 13C-NMR, mass spectral analysis and CHN analysis and they were evaluated for their anti-oxidant and anti-inflammatory studies. Among all the eighteen synthesized compounds,mostof the compounds exhibited excellent to very good anti-inflammatory and antioxidant activity.CompoundN-(4-{2-[(2-Nitro-benzylidene)-amino]-thiazol-4-yl}-phenyl)-benzamide (2c2) exhibited antioxidant activity and compound (N-[4-(2-Amino-thiazol-4-yl)-phenyl]-benzamide (2c) exhibited excellent anti- inflammatory and antioxidant activity.
