Abstract
The aim of this study is to deliver a drug into the brain via intranasal route using transfersomal in situ gel. For this purpose Carbamazepine (CBZ) which is used for the management of epilepsy was selected as a model drug. Transfersomes were formulated by thin film hydration method using Lipoid S100 and sodium cholate in 85:15% (W/W) concentration. Formed transfersomes were found to show the entrapment efficiency of 96.13±0.16%, 2.12±0.47μ particle size and cumulative CBZ release of 98.45% after 12hours. Developed transfersomes were further incorporated into in situ gel. The transfersomal in situ gel was formulated with plain Carbopol 934P and characterized for gelling ability and gelling strength. Formulation F2 with ++ gelling ability and 22±0.56 sec gelling strength was selected for further modification with HPMC K4M. Furthermore formulation F6 with +++ gelling ability, 31.87±1.21 sec gelling strength, 278±2cps viscosity for solution and 1120±20 cps for gel, 93.38% in vitro CBZ release and good mucoadhesive strength of 55.38±0.69 dyne/cm2 was optimized. From the results it can be concluded that transfersomal in situ gel of CBZ can be used to reduce the frequency of administration and increase patient compliance in the treatment of epilepsy.
