Abstract
The aim of the present study was to investigate the antioxidant and anti-urolithiatic effect of Terminalia bellirica Roxb. fruits on ethylene glycol-induced renal calculi in albino rats. Renal stone was induced in animals by 0.75% ethylene glycol in drinking water for 28 days. The test groups of animals were administered with methanolic extract of T. bellirica (MeTB) at the doses 100, 200 and 400mg/kg b.w. (p.o.) once in a day from 15th day to 28th day. Cystone (750 mg/kg body weight) was used as standard drug. The effect of T. bellirica on various physical and biochemical parameters in urine as well as in serum was evaluated. In vivo antioxidant activity and lithiatic markers were estimated in kidney homogenate. The results demonstrated that MeTB (400 mg/kg b.w.) significantly reduced the ethylene glycol induced disturbance in various physical and biochemical parameters in urine as well as in serum. MeTB (400 mg/kg b.w.) prevented the depletion of GSH level and decrease in the level of SOD in ethylene glycol induced renal injury in rats. In addition, MeTB also showed a significant decrease in the LPO levels signifying the potent antioxidant activity. All of our findings suggest that T. bellirica could protect the kidney from glycol induced calculi.
