Abstract
Outcome of Peptic Ulcer Disease (PUD) is more dangerous than others. Modern drugs used for the prevention and treatment of Ulcer cases may cause serious side effects. To overcome these problems, peoples now searching drug from the nature especially from plants. Hemidesmus indicus is one of the traditionally used plants for gastro intestinal disorders in the form of syrubath in Tamilnadu, India. In this study ethanolic extract of Hemidesmus indicus root (HIREE) is used to assay antiulcer potentials on acid alcohol induced ulcer model. The result revealed that HIREE reduces ulcer and showed 92% protection, which is greater than standard drug ranitidine. The level of antioxidant enzymes like LPO, SOD, catalase, GSH and GPx were restored as normal by HIREE 400mg/kg bw treatment. HIREE also provides hepatic protection along with ulcer protection, which is indicated by normal level of liver marker enzymes. Overall HIREE showed very effective for Ulcer prevention and treatment. HIREE will be considered as a safe drug for the treatment of ulcer with no side effects.
