Abstract
A new series of structurally diverse thienopyrimidines have been synthesized with the annulations of heterocyclic structural pharmacophores. All the newly synthesized compounds were characterized by IR, 1H and 13C NMR and LC-MS spectral studies and tested for their antioxidant and antibacterial activity. The 3-amino-4-(1-phenyl-2-(thieno[3,2-d]pyrimidin-4-ylsulfonyl)ethyl)isoxazol-5(4H)-one (14) showed excellent radical-scavenging activity when compared with the standard BHT. Hence the novel thienopyrimidine derivatives are considered as potent antioxidant and antibacterial agents.
