Abstract
Vigna trilobata (Linn.) is used in traditional system for the treatment of many ailments in Asia. The present study is an attempt to evaluate the antiemetic activity of V. trilobata (50 and 100 mg/kg of body weight) by using the chick emesis model. Different emetogenic stimuli such as, copper sulphate (CuSO4, oral), fresh juice of Brasica compestris (oral) and cisplatin (I.V) were used to induce emesis in 10-15 days old chicks of either sex. Antiemetic activity was assessed by calculating the mean decrease in number of retching in contrast with those of control. V. trilobata showed a significant antiemetic activity (p<0.05), when compared with standard antiemetic drugs, metoclopramide, domperidone and chlorpromazine. Further studies are under process, regarding the isolation and purification of active constituents responsible for the antiemetic activity of V. trilobata.
