Abstract
A novel synthetic pathway for synthesis of azobenzene-4,4’-dicarboxylic allyl ester as core linker is presented together with procedure for copolymerization of this linker with monomers methyl methacrylate and n-butyl methacrylate. The structure of synthesized cross linker was elucidated by infrared spectroscopy, nuclear magnetic resonance and mass spectroscopy. The comparative study of copolymers was done using In-vitro drug release of budesonide from capsule formulation through degradation in colonic media. From results it was concluded that Budesonide capsules coated with PMB1:1:2:A and PMB1:1:3:A showed maximum drug release in colon in a sustained release form.
