Abstract
A series of ten new dichalcones containing core s-triazine ring were synthesized using 2,4-bis(4-formylphenoxy)-6-methoxy-1,3,5-triazine as a template. The intermediate 2,4-bis(4-formylphenoxy)-6-methoxy-1,3,5-triazine was synthesized by the reaction of 2,4-dichloro-6-methoxy-1,3,5-triazine with sodium salt of 4-hydroxy benzaldehyde using phase-transfer catalyst. Thus, the prepared 2,4-bis(4-formylphenoxy)-6-methoxy-1,3,5-triazine has been subsequently treated with various acetophenones to afford title compound in excellent yields. We have developed a new method for the synthesis of intermediate 2,4-bis(4-formyphenoxy)-6-methoxy-1,3,5-triazine (5) using phase-transfer catalyst. The structures of intermediate and newly synthesized dichalcones were confirmed by physical and spectral analysis. All the dichalcones were evaluated for antibacterial and antifungal activities. Selected dichalcones showed good to excellent antibacterial and antifungal activities with reference to the well-established standards. Chloro-substituted compound (7b) showed highest antibacterial activity whereas methoxy-substituted compound (7i) showed highest antifungal activity.
