Abstract
An efficient route to series of 1,2,3-selenadiazoles by an oxidative cyclisation of 2-(1-phenylethylidene)hydrazinecarboxamide using 1,4-diazabicyclo [2.2.2] octane (DABCO) as an efficient catalyst. The advantages of this methodology are the ease of workup, simple reaction conditions, ecofriendly and mainly time-efficient process. The synthesized compounds 3(a-n) were evaluated for their analgesic and anti-inflammatory activity by using diclofenac sodium as a standard drug. Elemental analysis, 1H NMR, 13C NMR, and mass spectral data confirmed the structure of the synthesized compounds. The synthesized compounds 3g, 3n, exhibit effective activity as compared to standard drug diclofenac sodium.
