Abstract
The crushed seeds of Tamarindus indica and the crushed roots of Asparagus racemosus were soaked in water separately for 24 hours and then boiled for 1 hour and kept aside for 2 hours for the release of mucilage into water. After extraction with hot water and acetone treatment, the Tamarind seeds yielded 78% mucilage and Asparagus racemosus roots yielded 28% mucilage. Sustained release tablets of Diclofenac sodium were fabricated using Tamarindus indica, Asparagus racemosus mucilage and HPMC. The tablets were evaluated the physical characteristics like hardness, weight variation, friability and drug content. In-vitro release of drug was performed in phosphate buffer pH 6.8 for twelve hours. All the physical characters of the fabricated tablet were within acceptable limits. The tablet with HPMC (Batch C-I) exhibited greater drug content than those with natural tree mucilage and other batches of HPMC. A better sustained drug release was obtained with the matrix tablet made-up with the natural mucilage compared to HPMC polymer. It is cleared through the dissolution profile of Diclofenac sodium from matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent. In case of tablets prepared with Asparagus mucilage, almost maximum drug was released within 8-10 hours. Only at the highest concentration of mucilage (i.e.,14%),the drug release was found to sustain upto 12 hours in a steady manner.
