Abstract
Benzothiozoles are an important class of heterocyclic compounds which possess wide spectrum of biological properties. In the present research work, a series of new 2-substituted benzothiozole derivatives are synthesized and evaluated as enhanced antioxidant and antimicrobial agents. The chemical structure of newly synthesized 2-substituted benzothiazole derivatives are characterized by the spectral studies (IR, Mass and CHN analysis). The compounds were evaluated for their in -vitro antioxidant activity by using five standard protocols namely diphenyl picryl hydrazyl (DPPH) scavenging activity, nitric oxide scavenging activity, reducing power ability study, hydroxyl radical scavenging activity and by lipid peroxidation. Ascorbic acid was used as standard for DPPH, nitric oxide, reducing power ability and hydroxyl radical scavenging assay. Antibacterial activity was evaluated against B. pumilis, A. niger, S. aureous, C. albican and S. dysentriae using Norfloxacin, Ampicillin and Griseofulvin were standard. It was observed that the 2-substituted benzothiazole derivatives confirmed the antioxidant and antimicrobial activities.
