Abstract
Cinnamamides were prepared by using piperidine and different cinnamicacids. The structures of the newly synthesized compounds were confirmed by their IR, LC-MS, 1H & 13C NMR spectral data and tested in vitro for antibacterial activity against Gram-positive and Gram-negative bacterial strains. Most of the synthesized compounds showed moderate to good activity comparable to that of the standard drugs Streptomycin and Amphotericin B as an antibacterial and antifungal strain respectively. Compounds 4a and 4b exhibited good activity against Gram-positive bacterial strains S.aureus and B.subtilis respectively. Compounds 4a and 4i displayed good activity against fungal strains C.albicans and A.flavus respectively.
