Abstract

The objective of present work is to formulate, optimize and evaluates Raft forming tablet of Nizatidine for treatment of gastroesophageal reflux disease, heart burning. The aim of present study is to provide sustained effect of Nizatidine by using Sodium alginate and Pectin as raft forming agent and use sodium bicarbonate as gas generating agent.Raft formulation is newly imerging approch of Gastroretentive drug delivery system used to overcome the disadvantages associated with floating system. Thus raft formulation provide pH neutral barrier on stomach content which is used to reduce acidity and prevent reflux of acid into esophagus. Nizatidine is H2 antagonist absorbs from upper part of GIT and has a short biological half life so it will beneficial to retain in stomach. Raft forming tablet is evaluated by measuring Hardness, Thickness, Diameter, raft strength, raft weight, raft volume, in vitro drug release study, Weight variation, % drug content. 32 full factorial designs were used in present study for optimization. amount of sodium alginate and amount of sodium bicarbonate was used as an independent variable and raft strength, % drug release was used as dependent variable.A6 batch was optimized on based on maximum raft strength (6.11) and good in vitro drug release within 12 hr (98.96%).Stability study of optimized formulation showed that tablets were stable at accelerated Condition.It can be concluded that as the both polymer amount increase raft strength will increase and drug release in a sustain manner.By formulating raft forming tablet of nizatidine dose frequency will get reduced and patient compliance will increase.It can be conclude that raft forming tablet containing Nizatidine could be an efficient dosage form for treatment of heart burning, gastroesophageal reflux disease than all traditional antacids.